Table 4.
Allele and genotype frequencies in GD patients with or without ophthalmopathy and controls
| GENE | SNP | Alleles | Con (%) | GO (%) | P | non-GO (%) | P | P (GO/non-GO) |
|---|---|---|---|---|---|---|---|---|
| Sepp1 | rs6865453 | A | 1338 (74.5) | 173 (72.08) | 0.380 | 710 (73.20) | 0.462 | 0.7456 |
| C | 458 (25.5) | 67 (27.92) | 260 (26.80) | |||||
| AA | 491 (54.68) | 63 (52.5) | 257 (52.99) | |||||
| AC | 356 (39.64) | 47 (39.17) | 196 (40.41) | |||||
| CC | 51 (5.68) | 10 (8.33) | 32 (6.60) | |||||
| GPX4 | rs713041 | C | 1031 (57.41) | 136 (56.67) | 0.814 | 540 (55.67) | 0.410 | 0.8277 |
| T | 765 (42.59) | 104 (43.33) | 430 (44.33) | |||||
| CC | 300 (33.41) | 35 (29.17) | 156 (32.16) | |||||
| CT | 431 (48) | 66 (55) | 228 (47.01) | |||||
| TT | 167 (18.6) | 19 (15.83) | 101 (20.83) | |||||
| rs2074451 | G | 1004 (55.96) | 131 (55.51) | 0.867 | 531 (55.31) | 0.795 | 1 | |
| T | 790 (44.04) | 105 (44.49) | 429 (44.69) | |||||
| GG | 292 (31.44) | 33 (27.97) | 152 (31.67) | |||||
| GT | 440 (49.05) | 65 (55.08) | 227 (47.29) | |||||
| TT | 175 (19.51) | 20 (16.95) | 101 (21.04) | |||||
| rs3746165 | C | 1019 (56.74) | 128 (53.33) | 0.290 | 537 (55.36) | 0.541 | 0.6121 | |
| T | 777 (43.26) | 112 (46.67) | 433 (44.64) | |||||
| CC | 287 (31.96) | 31 (25.83) | 152 (31.34) | |||||
| CT | 445 (49.55) | 66 (55) | 233 (48.04) | |||||
| TT | 166 (18.49) | 23 (19.17) | 100 (20.62) | |||||
| SEPS1 | rs28665122 | C | 1688 (93.47) | 225 (93.75) | 0.887 | 909 (94.69) | 0.228 | 0.5304 |
| T | 118 (6.53) | 15 (6.25) | 51 (5.31) | |||||
| CC | 793 (87.82) | 105 (87.5) | 430 (89.58) | |||||
| CT | 102 (11.3) | 15 (1.25) | 49 (10.21) | |||||
| TT | 8 (0.9) | 0 (0) | 1 (0.21) | |||||
| rs7178239 | G | 802 (45.57) | 117 (50.87) | 0.121 | 443 (46.53) | 0.711 | 0.2401 | |
| C | 958 (54.43) | 113 (49.13) | 509 (53.47) | |||||
| GG | 180 (20.45) | 30 (26.09) | 102 (21.43) | |||||
| CG | 442 (50.23) | 57 (49.57) | 239 (50.21) | |||||
| CC | 258 (29.32) | 28 (24.34) | 135 (28.36) |