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. 2017 May 12;21:105. doi: 10.1186/s13054-017-1691-4

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Isolated brain mitochondrial respiration in cohort 1 animals. Red horizontal bars represent median values. Black filled circles represent animals that died during the resuscitation period. p Values provided were calculated with an independent-samples t test or the Mann-Whitney U test. State 3 represents active respiration after addition of adenosine diphosphate (ADP), and state 4 represents the respiration after depletion of ADP. The respiratory control ratio (RCR) was calculated by dividing state 3 by state 4 respiration rates. a Complex I. b Complex II. c Complex – IV