Table 4.
Regional blood flow in cohort 2
| Parameters | Group | BL | 3 h | 6 h | 12 h | End | p value | Time × group p valuea | Time p valuea | Group p valuea |
|---|---|---|---|---|---|---|---|---|---|---|
| Carotid artery | Lac ≥10% | 4.2 ± 0.9 | 3.8 ± 1.1 | 3.6 ± 0.5 | 3.2 ± 0.7 | 5.7 ± 2.6 | 0.030b | 0.077 | 0.458 | 0.078 |
| Lac <10% | 3.9 ± 0.9 | 4.1 ± 1.3 | 4.1 ± 1.4 | 5.0 ± 2.0 | 4.9 ± 1.6 | 0.457c | ||||
| 0.028c | ||||||||||
| Superior mesenteric artery | Lac ≥10% | 18.4 ± 8.0 | 17.7 ± 9.8 | 17.5 ± 6.6 | 18.8 ± 9.6 | 26.6 ± 11.0 | 0.010b | 0.858 | 0.179 | 0.807 |
| Lac <10% | 13.7 ± 2.9 | 15.7 ± 3.1 | 16.6 ± 3.4 | 18.2 ± 4.1 | 15.3 ± 7.6 | 0.028c | ||||
| Celiac trunk | Lac ≥10% | 9.2 ± 4.6 | 10.8 ± 3.4 | 9.8 ± 4.4 | 12.5 ± 3.9 | 11.8 ± 5.9 | 0.191b | 0.067 | 0.221 | 0.067 |
| Lac <10% | 8.8 ± 3.7 | 9.2 ± 4.1 | 9.9 ± 4.2 | 9.3 ± 5.0 | 7.0 ± 2.1 | |||||
| Hepatic artery | Lac ≥10% | 4.2 ± 3.7 | 5.2 ± 2.9 | 5.0 ± 3.0 | 6.3 ± 3.6 | 5.5 ± 2.6 | 0.232b | 0.100 | 0.149 | 0.142 |
| Lac <10% | 3.7 ± 1.8 | 3.0 ± 1.6 | 3.7 ± 1.8 | 3.6 ± 2.3 | 2.5 ± 0.9 | |||||
| Portal vein | Lac ≥10% | 20.5 ± 7.0 | 20.5 ± 11.5 | 19.2 ± 6.7 | 20.5 ± 8.4 | 27.4 ± 11.6 | 0.006b | 0.717 | 0.408 | 0.488 |
| Lac <10% | 19.3 ± 5.4 | 22.3 ± 5.6 | 21.8 ± 4.3 | 22.3 ± 6.0 | 17.3 ± 10.0 | 0.083c | ||||
| Total hepaticd | Lac ≥10% | 24.8 ± 8.2 | 25.7 ± 12.1 | 24.2 ± 8.0 | 26.8 ± 9.4 | 32.8 ± 13.0 | 0.006b | 0.371 | 0.224 | 0.965 |
| Lac <10% | 23.0 ± 5.4 | 25.3 ± 6.1 | 25.4 ± 4.7 | 25.9 ± 7.8 | 19.8 ± 10.1 | 0.040c | ||||
| Spleen artery | Lac ≥10% | 1.1 ± 0.4 | 1.1 ± 1.1 | 1.0 ± 0.8 | 1.2 ± 1.0 | 1.2 ± 1.2 | 0.049b | 0.115 | 0.341 | 0.766 |
| Lac <10% | 1.1 ± 0.3 | 1.5 ± 1.2 | 1.3 ± 0.8 | 1.2 ± 1.0 | 0.5 ± 0.2 | 0.167c | ||||
| Renal artery | Lac ≥10% | 5.2 ± 1.9 | 5.1 ± 1.4 | 4.4 ± 1.0 | 5.0 ± 1.0 | 3.9 ± 1.3 | 0.036b | 0.059 | 0.409 | 0.782 |
| Lac <10% | 5.8 ± 2.0 | 5.4 ± 2.1 | 5.7 ± 2.9 | 4.3 ± 2.7 | 2.1 ± 1.4 | 0.018c |
BL baseline, End End of experiment after 24 h of randomization or before death, if earlier
Values represent mean ± SD. All flows are in milliliters per kilogram per minute
a p Values were calculated with repeated-measures analysis of variance including time points 6 h and 12 h for time × group interaction, time effect, and group effect
bTime × group interaction with repeated-measures analysis of variance including all time points
cIndependent-samples t test at end of study
dSum of hepatic artery and portal vein blood flows