Table 2.
KEGG pathway analysis of upregulated and downregulated DMGs determined using Web Gestalt
| Rank | Name | Ratio | Observation/total | p-Value |
|---|---|---|---|---|
| hypermethylated genes | ||||
| 1 | Metabolic pathways | 0.041 | 48/1169 | 2.22E-06 |
| 2 | Pathways in cancer | 0.053 | 17/319 | 0.0005 |
| 3 | Regulation of actin cytoskeleton | 0.072 | 15/208 | 6.96E-05 |
| 4 | Focal adhesion | 0.070 | 13/186 | 0.0004 |
| 5 | Insulin signaling pathway | 0.091 | 12/131 | 6.96E-05 |
| hypomethylated genes | ||||
| 1 | Metabolic pathways | 0.091 | 107/1169 | 4.29E-22 |
| 2 | Pathways in cancer | 0.084 | 27/319 | 7.84E-05 |
| 3 | MAPK signaling pathway | 0.085 | 23/269 | 0.0002 |
| 4 | Endocytosis | 0.095 | 22/230 | 7.84E-05 |
| 5 | Focal adhesion | 0.112 | 21/186 | 1.46E-05 |