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. 2017 May 12;17:327. doi: 10.1186/s12885-017-3313-6

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Histopathology of the skin assessed near the necrotic border of digitus 3 of the left hand (Fig. 3) predominantly revealed altered tissue with fibrosis and strong mainly perivascular inflammatory infiltrates including lymphocytes, plasma cells, and neutrophils (a, b). The inflammatory infiltrate was dominated by CD4+ cells (c) when compared to CD8+ lymphocytes (d)