Table 3.
Association of Principal Component Factors with Clinical Outcomes in Chronic HF Cohort (HF-ACTION)
| Outcome: All-Cause Mortality or All-Cause Hospitalizations | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Unadjusted | Adjusted for age, gender, BMI | Adjusted for full prediction model* | |||||||
| Factor | HR (CI) | Wald χ2 | P | HR (CI) | Wald χ2 | p-value | HR (CI) | Wald χ2 | P |
| 3 | 1.13 (1.01, 1.27) | 4.33 | 0.04 | ||||||
| 5 | 1.31 (1.16, 1.48) | 17.72 | <.0001 | 1.30 (1.14, 1.48) | 15.51 | <.0001 | 1.24 (1.09, 1.42) | 10.49 | 0.001 |
| 7 | 1.18 (1.06, 1.32) | 8.88 | <0.01 | 1.15 (1.02, 1.29) | 5.33 | 0.02 | 1.16 (1.02, 1.31) | 5.46 | 0.02 |
| 9 | 0.82 (0.73, 0.93) | 10.61 | <0.01 | 0.85 (0.75, 0.97) | 6.15 | 0.01 | 0.88 (0.78, 0.99) | 4.00 | <0.05 |
| 13 | 0.89 (0.79, 1.00) | 3.85 | <0.05 | ||||||
| Outcome: All-Cause Hospitalization | |||||||||
| Unadjusted | Adjusted for age, gender, BMI | Adjusted for full prediction model* | |||||||
| Factor | HR (CI) | Wald χ2 | P | HR (CI) | Wald χ2 | p-value | HR (CI) | Wald χ2 | P |
| 1 | 1.48 (1.08, 2.05) | 5.81 | 0.01 | ||||||
| 2 | 1.67 (1.25, 2.22) | 11.95 | <0.001 | 1.56 (1.15, 2.14) | 7.91 | <0.05 | |||
| 5 | 1.61 (1.30, 1.99) | 19.61 | <.0001 | 1.59 (1.28, 1.97) | 18.02 | <.0001 | 1.42 (1.16, 1.74) | 11.35 | <0.001 |
| 8 | 1.57 (1.21, 2.04) | 11.64 | <0.001 | 1.43 (1.08, 1.90) | 6.23 | <0.01 | |||
| Outcome: Cardiovascular Death or Cardiovascular Hospitalization | |||||||||
| Unadjusted | Adjusted for age, gender, BMI | Adjusted for full prediction model* | |||||||
| Factor | HR (CI) | Wald χ2 | P | HR (CI) | Wald χ2 | p-value | HR (CI) | Wald χ2 | P |
| 5 | 1.33 (1.16, 1.52) | 17.74 | <.0001 | 1.31 (1.15, 1.50) | 15.66 | <.0001 | 1.22 (1.06, 1.39) | 8.14 | <0.01 |
| 8 | 1.26 (1.06, 1.50) | 6.66 | <0.01 | 1.22 (1.01, 1.47) | 4.30 | 0.038 | |||
| 9 | 0.86 (0.76, 0.98) | 5.51 | 0.01 | ||||||
| Outcome: Cardiovascular Death or Heart Failure Hospitalization | |||||||||
| Unadjusted | Adjusted for age, gender, BMI | Adjusted for all known predictors* | |||||||
| Factor | HR (CI) | Wald χ2 | P | HR (CI) | Wald χ2 | p-value | HR (CI) | Wald χ2 | P |
| 2 | 1.37 (1.08, 1.73) | 6.97 | <0.01 | 1.35 (1.06, 1.73) | 5.87 | 0.02 | |||
| 5 | 1.41 (1.20, 1.67) | 16.82 | <.0001 | 1.41 (1.19, 1.67) | 15.95 | <.0001 | 1.28 (1.09, 1.51) | 8.61 | <0.01 |
| 8 | 1.55 (1.27, 1.91) | 17.88 | <.0001 | 1.51 (1.22, 1.88) | 14.13 | <0.001 | |||
Hazard ratios (CI) are for 1 unit increase in factor. Any factor not listed above was not significant at p≤0.05 in any model. Grey spaces indicate factors consistently associated with the outcome after all adjustments. Blank spaces indicate that the factor was not significant at p≤0.05 in that model.
*
Adjusted for age, gender, race, geographic region, LVEF, BUN, presence of severe mitral regurgitation, medications, symptom scores, and measures from the baseline CPX test