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. 2017 Apr 4;7:595. doi: 10.1038/s41598-017-00734-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fractionation effect on cell survival. (a,b) Graphs report the hypothetical model curves for final surviving fraction of murine 3T3 (a) and human MCF-7 (b) cell lines that are isogenic for p27. The model was calculated using the survival fraction data obtained in the cell lines after a single dose of 2 Gy to estimate the survival fraction after a 50 Gy of fractionated treatment. Final surviving fraction after 25 treatments of 2 Gy can be anywhere between two (in 3T3 fibroblasts, proficient or deficient for p27) or five logs (human MCF-7 breast cancer cells deficient or proficient in p27 expression) of cell kill difference.