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. 2017 Apr 6;7:693. doi: 10.1038/s41598-017-00782-9

Figure 4.

Figure 4

Effect of MAPK inhibitors on SAA1-induced increase in p65 phosphorylation and decrease in IκBα abundance in human amnion fibroblasts. Effect of p38 inhibitor SB203580 (10 µM), ERK1/2 inhibitor PD98059 (20 µM) and JNK inhibitor SP600125 (20 µM) on SAA1 (10 ng/mL, 1 hour)-induced increase in p65 phosphorylation (A) and decrease in IκBα abundance (B) in human amnion fibroblasts. n = 5. Top panels are the representative immunoblots. Data are the means ± SEM. Statistical analysis was performed with one-way ANOVA test. **P < 0.01, ***P < 0.001 vs. control (0), #P < 0.05, ##P < 0.01 vs. SAA1.