Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Apr 6;7:693. doi: 10.1038/s41598-017-00782-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Role of TLR4 in the induction of IL-1β, IL-6 and COX-2 expression by SAA1 in human amnion fibroblasts. (A) Effect of siRNA-mediated knock-down of TLR4 on SAA1 (10 ng/mL, 24 hours)-induced changes in IL-1β, IL-6 mRNA (A, n = 4) and COX-2 mRNA and protein (B, n = 3) expression in human amnion fibroblasts. (B) Effect of TLR4 inhibitor on SAA1 (10 ng/mL, 24 hours)-induced changes in IL-1β, IL-6 mRNA (C, n = 4) and COX-2 mRNA and protein (D, n = 3) expression in human amnion fibroblasts. Top panels are the representative immunoblots. Data are the means ± SEM. Statistical analysis was performed with one-way ANOVA test. **P < 0.01, ***P < 0.001 vs. control (0) or NC, ^#P < 0.05, ^##P < 0.01, ^###P < 0.001vs. SAA1 or NC + SAA1.