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. 2017 Apr 6;7:672. doi: 10.1038/s41598-017-00796-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SIRT3 attenuates ERK1/2 activation in vivo and in vitro. (a) Caspase-3 activity in mice kidney. (b) Representative western blots for phosphorylated MAPKs (JNK, ERK, p38) in mice kidney. Data are mean ± s.d.; n = 6–8, *p < 0.05 versus the Ad-LacZ + NaF group, ^#p < 0.05 versus the Ad-SIRT3 + NaF group. (c) TCMK-1 cells were pretreated with 20 μM PD98059 for 2 h and then subjected to NaF for 12 h. (d) Caspase-3 activity in TCMK-1 cells. Data are mean ± s.d. of at least three independent experiments. **p < 0.01 versus the Scramble + NaF group, ^##p < 0.01 versus the SIRT3 + NaF group. Full-length blots/gels are presented in Supplementary Figure S22.