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. 2017 Apr 6;7:672. doi: 10.1038/s41598-017-00796-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SIRT3 decreased NaF-induced oxidative stress in mice kidney. (a) The F concentrations in the serum and renal tissues were measured. Plasma, μg/ml; Kidney, μg /g of dry tissue. (b) BUN level. (c) Serum creatinine level. (d) Mitochondrial O₂ ^•− level. (e) 8-OHdG content. (f) Reduced GSH content. (g) Representative western blots for SIRT3, Ac-SOD2, and SOD2 in mice kidney. (h) Immunohistochemical analysis of SOD2 (acetyl K68) expression in kidney tissue. (i) SOD2 activity was determined. Data are mean ± s.d.; n = 6–8. **p < 0.01 versus the Ad-LacZ + NaF group, ^#p < 0.05, ^##p < 0.01 versus the Ad-SIRT3 + NaF group. Full-length blots/gels are presented in Supplementary Figure S21.