Table 2.
Ingenuity pathway analysis (IPA) of miRNA, RORA and NR2E3 target genes.
| E18 Network Function | Genes |
|---|---|
| Cardiovascular | ANTXR2, ARHGEF3, ASPN, B3GNT9, BMP7, CAST, DSC2, DSG2, EGLN3, EHF, ELL2, ETSS1, FAM46A, FGFR2, FOXC1, GATM, GRHL2, HAS2, JAG1, LAMC1, LAMP2, LRIG1, MGLL, MUC4, NTRK2, OSR1, PPARGC1A, PRDM16, PTPRB, RSPO1, RYR1, SEMA3C, SEMA3D, SGMS1, SLC7A8, TGFBR2, TGFBR3, THBS1, THBS2, TRDN, WNT4 |
| Immune Response/Injury | CD44, COL18A1, DPT, EGFL6, ELK3, ENTPD1, FGL2, FOSL2, FRAS1, KCNQ5, LPP, LYZ, MYRF, NPR3, OTX1, RAB27A, RGS5, VCAN |
| Cellular Function | ALCAM, ARAP2, BACH2, BMF, BNC2, CCND2, CD36, CRHBP, CSPG4, DLK1, DST, ELOVL7, FLRT2, IFI202B, IL13RA1, ITGB3, LCP1, MYLK4, PPFIBP2, PPP1R3B, PRDM1, SCARA5, SGMS2, SHE, STAT6, TBX22, TEK, TFCP2L1, UNC45B |
| Development | ACER2, CGNL1, CRIM1, DMRTA2, EPB41L1, FBN2, FNDC3B, FOXC1, FZD4, GBP7, JADE2, JAG1, LPAR1, MATN2, MEF2C, MSRB3, MYOT, PAPSS2, PEG3, PGM5, RBSM1, SLC16A12, SMOC2, SSPN, STARD8, TRP63, VAMP5 |
| Molecular Transport | ABCA9, CD248, FAM174B, FAM84A, FNDC1, ITPRIPL2, LRFN2, PIEZO2, PRTG |
| Metabolism | AFAP1L2, ARHGAP36, CXCL12, EEF2K, FRK, HMCN1, NOX4, PTGFRN |
| Vision | CGNL1, CRIM1, DMRTA2, EPB41L1, FBN2, FNDC3B, FZD4, KIAA1522, MATN2, MSRB3, PAPSS2, PGM5, RBSM1, SLC16A12, STARD8, VAMP5 |
| PN Network Function | Genes |
| Cardiovascular | ARG1, BACH2, BMP7, BOC, CAV3, CD44, COL25A1, DLK1, ELK3, ETS1, FLT1, FOXC1, HAPLN1, HAS2, JAG1, LAMC1, LCP1, LPP, NOX4, NRP2, NTRK2, OSTF1, RSPO1, SEMA3C, SEMA3D, SLC7A8, SULF1, TEK, TGFBR3, THBS2, VCAN, WNT4 |
| Structure | ABCA1, ABCC9, B3GNT9, CASP12, CCBE1, CCND2, CD55, CD93, EHF, ELL2, FAM46A, IL13RA1, OSR1, PPARGC1A, PRDM1, STAT6, UCP2 |
| Hematological Disease | FAM101B, FAM114A1, FAM174B, FAM84A, FZD6, KDELC2, MSRB3, PAPSS2, PDLIM7, PIEZO2, PRICKLE1, SGMS2, TMEM164, VAMP5 |
| Cellular Function | ACPP, DPT, EEF2K, EGFL6, EHD4, ENTPD1, FOSL2, FRAS1, LMO7, LYZ1, MYRF, OTX1, RGS5, SDPR, TNNT2 |
| Immune Response/Injury | ASPN, BNC2, CPM, DENND2C, FBN2, FIBIN, FNDC1, ITPRIPL2, NEBL, PPP1R3B, STARD8, TBX18 |
| Metabolism | CRHBP, DEK, DMRTA2, FBXL7, GATM, NRK, RBSM1, SGMS1, SMPX, TFCP2L1, DST, ELOVL7, MYLK4, PGM5, TBX22, UNC45B, SLC7A10 |
| Development | ACER2, DSG2, EGFR, FZD4, LMNA, MEF2C, PEG3, SSPN, TRP63 |
Genes regulated by NR2E3 are in bold; genes regulated by RORA are in italics, and genes regulated by NR2E3 and RORA are bold and italics.