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. 2017 Apr 6;7:711. doi: 10.1038/s41598-017-00764-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Results of Rosetta modelling of IL1 variants. Results of Rosetta modelling are shown for three typical loop variants: CC/UU (a), CA/UU (b), and CU/UU (c). Top: secondary structure of IL1 used as input to Rosetta modelling; that is, the input structure was ((..((+))..)) for all three sequences. Middle: interactions identified by rnaview in Rosetta’s top model; standard cWW base pairs are marked by double lines; all “loop” nucleotides are paired in cWW conformation; for the basepairing nomenclature of Leontis & Westhof⁷⁷ see Supplementary Fig. S1. Bottom: Logos produced by RNAredesign for Rosetta’s top model.