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. 2017 Apr 6;7:711. doi: 10.1038/s41598-017-00764-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histone mRNA stem-loop. This hairpin loop including the closing base pair is identical in sequence to PSTVd’s HP (Fig. 5a). (a) Comparison of hairpin loops of PDB entries 1JU7 (red), 1KKS (cyan), and 4QOZ (gold); model 5 of 1JU7 and model 8 of 1KKS are shown, which are annotated as best structures in their respective PDB files. Views from different angles are shown in Supplementary Fig. S4. (b) Hairpin loop (cartoon in gold) from 4QOZ, bound by Exo (cartoon in lightpink) and SLBP (cartoon in darkgreen); a few amino acid side chains, which interact with RNA backbone and bases, are labelled. (c) Logo of 11,099 histone mRNA loops from Rfam-11⁷⁹ (ID: Histone3); three sequences have an additional nucleotide after position 6. (d) Logo of 36 non-redundant histone mRNA loops from Rfam-11.