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. 2017 Apr 4;7:605. doi: 10.1038/s41598-017-00741-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation networks of CD4⁺ T-cell surface proteins in control individuals, patients with non-exudative age-related macular degeneration (AMD), and patients with exudative AMD. The relationships between surface proteins are calculated using Spearman’s correlation and the correlation coefficient is marked when ≥0.4 or ≤−0.4 using green or red lines, respectively. Differences in relationship patterns reveal that a complex systemic immune dysfunction may be present in patients with AMD.