Table 3.
Correlations between increasing age and CD4+ T-cells surface proteins are present in control individuals (CD4+CXCR3+, CD4+CXCR3+IL12RB2+, and CD4+CXCR3+CCR6+), but not in patients with non-exudative or exudative age-related macular degeneration (AMD).
| Controls (n = 30) | Non-exudative AMD (n = 24) | Exudative AMD (n = 30) | ||||
|---|---|---|---|---|---|---|
| ρ | p-value | ρ | p-value | ρ | p-value | |
| Th1 (CD4+CXCR3+IL12RB2+)a | −0.53 | 0.002 | −0.20 | 0.343 | −0.05 | 0.802 |
| Th17 (CD4+CCR6+ IL23R+)a | +0.01 | 0.957 | −0.05 | 0.810 | +0.10 | 0.611 |
| Th17/Th1 ratiob | +0.69 | <0.001 | −0.17 | 0.418 | −0.11 | 0.572 |
| CD4+IL12RB2+a | −0.15 | 0.420 | −0.04 | 0.847 | +0.21 | 0.256 |
| CD4+IL23R+a | −0.04 | 0.817 | −0.25 | 0.243 | +0.15 | 0.439 |
| CD4+CXCR3+a | −0.46 | 0.010 | −0.17 | 0.426 | −0.31 | 0.092 |
| CD4+CCR6+a | +0.14 | 0.476 | −0.08 | 0.727 | −0.19 | 0.319 |
| CD4+CXCR3+CCR6+b | −0.46 | 0.011 | −0.25 | 0.246 | −0.26 | 0.172 |
Abbreviations: n = number; AMD = age-related macular degeneration; Th1 = T helper 1; Th17 = T helper 17. Correlation coefficients (ρ) and p-values are calculated using: aPearson’s correlation; bSpearman’s correlation. Cell populations with significant differences are greyed out.