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. 2017 Apr 3;7:554. doi: 10.1038/s41598-017-00709-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Physicochemical characterizations of developed SOF/TIBA/PLGA MSs. (A) FE-SEM images of SOF/TIBA/PLGA MSs are shown. The length of scale bar is 10 µm. (B) Size distribution charts of SOF/TIBA/PLGA MSs are presented. (C) FE-SEM images of SOF/TIBA/PLGA20 MSs at day 0 and day 28 after incubation in serum (50% FBS) are exhibited. The length of scale bar is 10 µm.