Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Pharmacokinetic parameters of SOF after oral and IA administration in rats.
| Parameter | SOF solution (oral) | SOF/TIBA/PLGA20 MSs (IA) |
|---|---|---|
| AUC (μg∙min/mL) | 6804.0 ± 2650.1 | 717.6 ± 155.3* |
| AUC/D ((μg · min/mL)/(mg/kg)) | 680.0 ± 265.0 | 717.6 ± 155.2 |
| Cmax (ng/mL) | 3048.7 ± 1356.5 | 196.2 ± 26.3* |
*p < 0.05, compared with SOF solution (oral administration) group.
Doses of oral and IA administration were 10 and 1 mg/kg, respectively.
Data present as means ± SD (n ≥ 3).
