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. 2017 Apr 4;7:626. doi: 10.1038/s41598-017-00725-4

Table 1.

The comparison table between the proposed LDPA techniques with the existing dual-pulse nonlinear PA technique.

Dual-pulse nonlinear PA Proposed LDPA by CW laser excitation Proposed LDPA by Quasi-CW laser excitation
Physical mechanism
Nonlinear origin Impulse temperature rise then heat relaxation during laser interval Continuous temperature rise and heat accumulation Quasi-continuous temperature rise and heat accumulation
Physical conditions Thermal and stress confinements satisfied for two PA generations First PA signal: satisfied Second PA signal: unsatisfied Thermal and stress confinements satisfied for all PA signals
PA generation mechanism Two laser pulse induce two PA signals One laser pulse induce two PA signals N consecutive laser pulses induce N PA signals
System performance
Heating efficiency ×Low (single short laser pulse heating) √ High (continuous laser heating) √ High (Quasi-continuous laser heating)
PA signal strength √ High (high peak power pulsed laser) ×Low (low-power CW laser) √ High (high peak power pulsed laser)
System cost ×Very high (two high-power laser systems required) √ Very low (single CW laser diode) √ Low (single high-rep-rate pulsed laser diode)
Applications ×Need tight focusing to improve the heating efficiency and nonlinearity (e.g. time-reversal optical focusing in scattering medium) ×Need strong absorber and focusing to improve the PA SNR (e.g. contrast-enhanced PA microscopy) √ Generally applicable to most PA embodiments (e.g. PA tomography, microscopy, endoscopy, etc.)