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. 2017 Apr 10;7:766. doi: 10.1038/s41598-017-00774-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Electron micrographs of EP1-iPSCs derived retina cups at 160 days. (a) A one-micron thick section of a plastic embedded retina cup. Highlighted boxes (B’ and C’) are represented in panels (b) and (c) respectively. Arrows indicated in panel (b) represent cones while those in (c) indicate rods. 50 nm ultra-thin sections were imaged by standard EM. (d) Microvilli (mv) present on the surface of isolated RPE clumps RPE and pigment (p) within; (e) a PR inner segment with a connecting cilium (cc), mitochondria (mt), a centriole (ct), and basal body (bb); (f) a PR with a connecting cilium bearing a rudimentary outer segment with stacks of discs (arrows). (F1) Panel illustrates a cross section of a POS bearing organized discs while (F2) shows the basal body and centriole; (g) a PR inner segment with an intact outer limiting membrane; (h) a PR synaptic terminal with synaptic vesicles (arrowheads) docked at electron dense ribbons (arrows). PR = photoreceptor, RC = retina cup; RPE = retinal pigment epithelium. Scale bars (a) = 300 μm, (d) = 4 μm, (e) = 1 μm, (f) = 1 μm, F1 = 500 nm, (g) = 1 μm, (h) (inset) = 200 nm, (h) = 1 μm.