Table 2.
Meta-analyses combining Oulu, Tampere, Kuopio and Helsinki screening results.
| Mutationa | Cohortb | OR | 95% CI | p-valuec | Oulu Mut/WT | Tre Mut/WT | Kuo Mut/WT | Hki Mut/WT |
|---|---|---|---|---|---|---|---|---|
| TEX15 | All BC | 1.0 | 0.6–1.8 | 0.959 | 16/1530 | 1/86 | NA | 9/977 |
| c.8325G > A | Hereditary BC | 1.6 | 0.8–3.1 | 0.208 | 6/222 | 1/86 | NA | 9/977 |
| rs146619272 | Controls | 13/1190 | 0/94 | NA | 10/1078 | |||
| FANCD2 | All BC | 1.6 | 0.6–4.1 | 0.375 | 4/1376 | 2/731 | 0/668 | 7/2506 |
| c.2715 + 1G > A | Hereditary BC | 2.6 | 0.8–9.1 | 0.131 | 2/226 | 0/87 | NA | 4/1171 |
| rs201811817 | Unselected BC | 1.3 | 0.4–3.6 | 0.675 | 2/1150 | 2/644 | 0/668 | 4/1723 |
| Controls | 2/1226 | 2/765 | 0/156 | 2/1270 | ||||
| RNF168 | All BC | 0.7 | 0.5–1.2 | 0.211 | 12/1410 | 1/531 | 17/635 | 7/1163 |
| c.640_644del5 | Hereditary BC | 0.9 | 0.4–2.0 | 0.757 | 3/225 | 0/87 | NA | 7/1163 |
| rs777601326 | Unselected BC | 0.7 | 0.4–1.3 | 0.241 | 9/1185 | 1/444 | 17/635 | NA |
| Controls | 6/1179 | 4/409 | 13/275 | 11/1261 |
a TEX15 c.7253dupT was excluded from the meta-analysis since the mutation was present only in the Northern Finnish cohort. bAll the known BRCA1/2 carriers were excluded from the meta-analyses. cLogistic regression model, all the analyzed cohorts combined and all individual datasets exploited. CI: confidence interval, BC: breast cancer, Hki: Helsinki, Kuo: Kuopio, Mut: mutation carrier, NA: not available, OR: odds ratio, Tre: Tampere, WT: wild type.