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. 2017 Apr 7;7:732. doi: 10.1038/s41598-017-00826-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Identification of insulin-like growth factor (IGF)-1-mediated micro (mi)RNA signature by in silico and in vitro analyses. (A) The Venn diagram shows that four candidate miRNAs were identified in both TCGA miRNA array and IGF-1-treated U87-MG miRNA array data. Six and 179 IGF-1-downregulated miRNAs were respectively obtained from 312 TCGA miRNA arrays of GBM patients with different IGF-1 levels and the miRNA array analysis with 200 ng/ml IGF-1-treated U87 MG cells for 48 h (with a multiple of change (MC) of <0.75 and a false discovery rate (FDR) of <0.05). The four candidate miRNAs were identified in both miRNA array datasets. Expression correlations between IGF-1 and IGF-1-downregulated miRNAs included miR-9-5p (B), miR-9-3p (C), miR-181d (D), and miR-130b (E) in TCGA GBM data (n = 519). The correlations were measured by Spearman’s correlation analyses. (F) The list shows 11 putative target genes of miR-181d with an inverse correlation.