Table 1.
Animal characteristics and brain composition.
| WKY | SHR | t-test | |
|---|---|---|---|
| Weight | |||
| Body (gr) | (n = 20) 404 ± 5 | (n = 19) 372 ± 5 | p < 0.001 |
| Brain (gr) | (n = 20) 2.26 ± 0.01 | (n = 19) 2.12 ± 0.03 | p < 0.001 |
| Blood Pressure | |||
| Systolic | (n = 20) 163 ± 4 | (n = 19) 189 ± 4 | p < 0.001 |
| Diastolic | (n = 20) 118 ± 5 | (n = 19) 146 ± 4 | p < 0.001 |
| BPM | (n = 20) 378 ± 8 | (n = 19) 460 ± 5 | p < 0.001 |
| Water content | |||
| % | (n = 6) 77.155 ± 0.021 | (n = 6) 77.612 ± 0.1 | 0.052 |
| Ions | |||
| Na+ (mmol/ml Water) | (n = 6) 0.060 ± 0.001 | (n = 6) 0.062 ± 0.001 | 0.117 |
| K+ (mmol/ml Water) | (n = 6) 0.111 ± 0.002 | (n = 6) 0.106 ± 0.001 | 0.004 |
| Na+ to K+ ratio | (n = 6) 0.539 ± 0.012 | (n = 6) 0.592 ± 0.011 | 0.008 |
SHR body weight and brain weight were lower as compared to WKY. Systolic and diastolic blood pressure, and heart rate were elevated in SHR. Water content in SHR brain tended to be higher as compared to WKY. Whole brain sodium concentration was not different, but the potassium concentration was significantly lower in SHR brain as compared to WKY. Data are mean ± SEM.