Table 2.
Comparisons between WT and P2Y6-KO mice with respect to parameters associated with bladder contraction.
| p1 (s) | p2 (s) | p3 (s) | p4 (s) | p1 rise (mmHg/s) | p2 descent (mmHg/s) | p3 rise (mmHg/s) | p4 descent (mmHg/s) | |
|---|---|---|---|---|---|---|---|---|
| WT | 5.0 ± 0.8 | 4.2 ± 0.5 | 1.2 ± 0.3 | 12.8 ± 0.9 | 3.9 ± 0.4 | −3.9 ± 0.5 | 1.8 ± 0.7 | −0.7 ± 0.1 |
| (2.6–10.9) | (2.2–7.4) | (0.2–3.6) | (8.6–17.0) | (2.0–6.3) | (−6.6–−2.5) | (−0.5–8.0) | (−1.1–−0.4) | |
| KO | 2.4 ± 0.3** | 1.8 ± 0.3*** | 1.4 ± 0.2 | 9.0 ± 0.9** | 7.4 ± 1.0** | −5.4 ± 0.3* | 1.0 ± 0.2 | −1.2 ± 0.1*** |
| (1.3–3.5) | (0.5–3.5) | (0.2–2.4) | (4.9–12.6) | (3.1–12.4) | (−7.0–−3.7) | (−0.5–2.5) | (−1.5–−0.9) |
The symbols of p1, p2, p3, and p4 indicate 1st, 2nd, 3rd, and 4th phases, respectively, of BCD. The p1 rise, p2 descent, p3 rise, and p4 descent are calculated as: (pressure change from PT to MVP)/p1, (pressure change from MVP to TP)/p2, (pressure change from TP to CPP)/p3, and (pressure change from CPP to RP), respectively. Numbers in parentheses are ranges. Significant difference from variable of WT mice: *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired t-test or Mann-Whitney U test, according to the result of D’Agostino & Pearson omnibus normality test). Values are expressed as the mean ± SEM (n = 10 for each).