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. 2017 Apr 7;7:729. doi: 10.1038/s41598-017-00855-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Progression of different LV parameters as evaluated by echocardiography during the duration of the study (26 weeks). Δ: % difference between week 0 and week 26, EDD: end-diastolic diameter (A), ESD: end-systolic diameter (B), SW: septal wall thickness (C), PW: posterior wall thickness (D), RWT: relative wall thickness (E), mWS: mean wall stress (F), FS: fractional shortening (G), SV: stroke volume (H) and CO: cardiac output (I). The results are reported in % as the mean ± SEM (n = 7–11/gr). Probability values from a 2-way ANOVA and Holm-Sidak post-testing to evaluate the p value of sex, (S), disease (D) or disease-sex interactions (S × D) are shown next to each panel.