Table 1.
List of representative dysregulated genes between APFL and AP.
| Gene name | Description | Log2 (Fold change) | Functions | Significance (P-value) |
|---|---|---|---|---|
| Log2 (APFL/AP) | ||||
| RT1-A3 | Uncharacterized protein | 18.07504 | Positive regulation of T cell mediated cytotoxicity | Yes (1.32E-05) |
| MSC | Musculin | 12.34538 | Negative regulation of transcription from RNA polymerase II promoter | Yes (9.45E-04) |
| FBXO27 | F-box protein 27 | 11.24744 | Glycoprotein binding | Yes (1.76E-07) |
| MSX1 | Msh homeobox 1 | 10.72489 | Negative regulation of cell growth | Yes (3.39E-04) |
| RGD1561212 | Similar to RIKEN cDNA | 10.69475 | Exhibits retinoic acid receptor binding | Yes (1.46E-07) |
| SIGLEC8 | Sialic acid binding Ig-like lectin 8 | 9.65489 | Intracellular signal transduction | Yes (2.15E-05) |
| RAMP3 | Receptor (G protein-coupled) activity modifying protein 3 | 9.49772 | Regulation of G-protein coupled receptor protein signaling pathway | Yes (3.41E-18) |
| ZFYVE28 | Zinc finger, FYVE domain containing 28 | 9.45763 | Negative regulation of epidermal growth factor | Yes (7.88E-09) |
| TNFAIP6 | Tumor necrosis factor alpha induced protein 6 | 9.33946 | Negative regulation of inflammatory response | Yes (1.36E-06) |
| AOC1 | Amine oxidase, copper containing 1 | 9.18586 | Amine metabolic process | Yes (1.03E-04) |
| TNN | Tenascin N | 8.82202 | Cell-matrix adhesion | Yes (4.54E-07) |
| PTX3 | Pentraxin 3 | 8.80702 | Innate immune response | Yes (1.73E-06) |
| LMX1A | LIM homeobox transcription factor 1 alpha | 8.36729 | Regulation of transcription, DNA-templated | Yes (1.65E-04) |
| RASEF | RAS and EF hand domain containing | 7.90165 | Rab protein signal transduction | Yes (1.77E-04) |
| LOC497963 | Similar to Nitric oxide synthase | 7.78913 | Nitric oxide biosynthetic process | Yes (2.15E-03) |
| DGKH | Diacylglycerol kinase | 7.55722 | Protein oligomerization | Yes (4.43E-06) |
| SLC7AL1 | Solute carrier family 7, member 11 | 7.18928 | Response to oxidative stress | Yes (7.32E-06) |
| DNM3 | Dynamin 3 | 5.22016 | Anatomical structure development | Yes (1.46E-07) |
| LRRC8E | Leucine rich repeat containing 8 family | 5.07676 | Ion transport | Yes (2.36E-06) |
| VWA2 | Von Willebrand factor A domain containing 2 | 4.13783 | Regulation of insulin receptor signaling pathway | Yes (2.53 E-03) |
| EGR2 | Early growth response 2 | 4.11453 | Cellular protein modification process | Yes (5.49 E-06) |
| FOSL2 | Fos-like antigen 2 | 4.03226 | Positive regulation of fibroblast proliferation | Yes (1.49 E-03) |
| TREM1 | Triggering receptor expressed on myeloid cells 1 | 3.94884 | Neutrophil chemotaxis | Yes (3.92 E-03) |
| FOSL1 | Fos-like antigen 1 | 3.30191 | Neurological system process | Yes (1.80 E-05) |
| GAS1 | Growth arrest-specific 1 | 2.79755 | Negative regulation of mitotic cell cycle | Yes (1.10E-20) |
| WDR4 | WD repeat domain 4 | 1.30914 | tRNA methylation | Yes (8.61E-03) |
| PTPRM | Protein tyrosine phosphatase, receptor type, M | −1.0036 | Peptidyl-tyrosine dephosphorylation | Yes (1.55 E-04) |
| CDKN1C | CDKI protein long isoform | −1.71620 | Cell cycle arrest | Yes (6.87 E-03) |
| UBD | Ubiquitin D | −2.32347 | Protein ubiquitination | Yes (2.83E-06) |
| RGMA | Repulsive guidance molecule family member A | −2.87523 | Negative regulation of collateral sprouting | Yes (8.81E-19) |
| BRDT | Bromodomain, testis-specific | −2.90388 | Chromatin remodeling | Yes (4.13 E-03) |
| CD8A | CD8a molecule | −3.37913 | Response to stress | Yes (6.91E-06) |
| FOXH1 | Forkhead box H1 | −3.95036 | Anatomical structure development | Yes (9.49E-23) |
| PDE3A | Phosphodiesterase 3A | −4.67631 | Small molecule metabolic process | Yes (4.37E-06) |
| TFF3 | Tff3 molecule | −4.82677 | Regulation of glucose metabolic process | Yes (5.44E-04) |
| OTOGL | Otogelin-like | −6.85145 | Sensory perception of sound | Yes (6.46 E-04) |
| NPR3 | Natriuretic peptide receptor 3 | −8.79741 | Negative regulation of adenylate cyclase activity | Yes (1.81E-03) |
| LOC100360055 | Cytochrome P450 2B15-like | −9.82802 | Xenobiotic metabolic process | Yes (8.93E-05) |
| MMD2 | Monocyte to macrophage differentiation -associated 2 | −10.26003 | Protein phosphorylation | Yes (2.30E-08) |
| CML3 | Camello-like 3 | −10.90368 | Gastrulation with mouth forming second | Yes (1.13E-13) |
| ALDH1A7 | Aldehyde dehydrogenase family 1 | −13.13943 | Oxidation-reduction process | Yes (3.74E-28) |