Table 2.
Distribution of HMOX genotypes (GT fragment length) between the study groups (GS, C).
| All subjects (n = 111; 100%) | (GT)n-repeats [S < 26; L > 30 bp]° | Distribution of HMOX genotypes and corresponding UCB levels | |||
|---|---|---|---|---|---|
| GS n (%) | GS UCB [µM] | C n (%) | C UCB [µM] | ||
| SS | 3 (5.4) | 37.8 (±13.3) | 3 (5.5) | 8.1 (±2.9) | |
| SM | 24 (42.9)* | 33.4 (±8.3) | 19 (34.5) | 8.6 (±3.4) | |
| SL | 3 (5.4) | 37.2 (±6.4) | 2 (3.6) | 8.8 (±0.4) | |
| MM | 19 (33.9) | 31.7 (±10.5) | 25 (45.5)* | 9.9 (±3.7) | |
| ML | 7 (12.5) | 32.7 (±10.7) | 6 (10.9) | 8.5 (±3.4) | |
| Males ( n = 73 ; 100 %) | |||||
| SS | 2 (5.4) | 41.5 (±16.5) | 2 (5.6) | 9.3 (±2.9) | |
| SM | 15 (40.5)* | 35.8 (±9.3) | 15 (41.7)* | 8.9 (±2.9) | |
| SL | 2 (5.4) | 40.4 (±4.2) | 1 (2.8) | 9.1 (±0.0) | |
| MM | 15 (40.5)* | 32.4 (±11.3) | 15 (41.7)* | 10.5 (±3.9) | |
| ML | 3 (8.1) | 37.5 (±8.0) | 3 (8.3) | 8.0 (±4.2) | |
| Females ( n = 38 ; 100 %) | |||||
| SS | 1 (5.3) | 30.6 (±0.0) | 1 (5.3) | 5.6 (±0.0) | |
| SM | 9 (47.4)* | 29.5 (±4.4) | 4 (21.1) | 7.1 (±3.2) | |
| SL | 1 (5.3) | 30.6 (±0.0) | 1 (5.3) | 8.5 (±0.0) | |
| MM | 4 (21.1) | 28.9 (±7.4) | 10 (52.6)* | 9.2 (±3.3) | |
| ML | 4 (21.1) | 29.1 (±12.7) | 3 (15.8) | 8.9 (±3.1) | |
Table 2 specifies the distribution of HMOX-genotypes in terms of GT fragment lengths (GT-repeats) in the respective study groups (all subjects and divided by gender), and the corresponding UCB levels (mean ± sd). No statistical significance was reached. However, non-significantly in GS subjects shorter alleles (SM) occurred more frequently than in C, where the MM genotype was more common. The effect was only present in females. UCB levels non-significantly decreased, as GT-repeats increased. °Cut-off levels for classification of GT fragment lengths were adopted from Chang et al.72. Abbreviations: SS: short/short; SM: short/medium; SL: short/long; MM: medium/medium; ML: medium/long GT fragment length (repeats); GS: Gilbert’s Syndrome; C: Controls. *Most frequently occurring genotype in respective group.