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. 2017 Apr 6;7:717. doi: 10.1038/s41598-017-00851-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Nicotinamide mononucleotide (NMN) treatment protects against cICH-induced brain injury. (A) NAD⁺ level in brain tissue was measured at 2 hours after injection of NMN from tail vein. *P < 0.05 vs Vehicle; NS, no significance. N = 6 per group. (B) Brain hematoma volume at 24 hours after cICH. n = 8 per group. (C) Body weight at 24 hours after cICH. ***P < 0.001 vs Sham, n = 22, 60 and 63 in Sham, cICH + Vehicle and cICH + NMN groups respectively. (D) Hemoglobin content at 24 hours after cICH. n = 8 per group. (E) Brain water content at 24 hours after cICH in cortex and striatum. **P < 0.01 cICH + Vehicle vs Sham, *P < 0.05 cICH + NMN vs cICH + Vehicle, n = 8. (F) Neurological deficit was evaluated by beam walking test at 24 hours after cICH. **P < 0.01, n = 26, 69 and 73 in Sham, cICH + Vehicle and cICH + NMN groups respectively. NS, no significance.