Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Apr 12;7:847. doi: 10.1038/s41598-017-00977-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

TLR7 expression in mouse atherosclerotic lesions. (A) Rabbit-anti-mouse TLR7 monoclonal antibody immunostaining of a normal mouse aortic arch. Scale: 1 mm, inset scale: 200 µm. (B) Rabbit-anti-mouse TLR7 monoclonal antibody immunostaining of an aortic arch from an Apoe ^−/− mouse with atherosclerosis showed TLR7 expression in intima and adventitia. Scale: 1 mm, inset scales: 200 and 68 µm. Arrows indicate TLR7-positive cells. (C) Rabbit IgG isotype immunostaining of a parallel aortic arch from an Apoe ^−/− mouse with atherosclerosis. Scale: 1 mm, inset scale: 200 µm. (D–F) Immunofluorescent double staining of mouse aortic arch atherosclerotic lesions with antibodies against TLR7 and cell type markers (Mac-2, α-actin, and CD31) for macrophage, SMC, and EC from both the lumen and adventitia microvessels. Scale: 100 µm, inset scale: 25 µm. Arrows in the insets indicate TLR7-positive macrophages (D), SMCs (E), and ECs in lumen and adventitia (F).