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. 2017 Apr 12;7:847. doi: 10.1038/s41598-017-00977-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TLR7 deficiency and aortic arch atherosclerotic lesion inflammatory cell accumulation in male Apoe ^−/− mice. (A) Mac-3-positive area in pixel. (B) Lesion CD4⁺ T-cell number. (C) Lesion MHC class-II-positive area in pixel. (D) Mac-3-positive area versus total lesion area in percentage. Representative images are shown to the right. Scale: 200 µm, inset scale: 100 µm. (E) Lesion CD4⁺ T-cell number per mm². Representative images are shown to the right. Scale: 100 µm. (F) Lesion MHC class-II-positive area versus total lesion area in percentage. Representative images are shown to the right. Scale: 100 µm. Numbers and genotypes of mice are indicated in the legends.