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. 2017 Apr 12;7:847. doi: 10.1038/s41598-017-00977-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TLR7 deficiency changes aortic arch atherosclerotic lesion inflammatory cytokine and protease expression in male Apoe ^−/− mice. (A) Plasma IL6 level. (B) Lesion IL6-positive area percentage. Representative images are shown in the middle panels. Rabbit IgG isotype control staining results from parallel sections are show in the right panels. Scale: 200 µm. (C) Lesion IL4-positive area percentage. (D) Lesion TGF-β-positive area percentage. (E) Plasma SAA level. Lesion TLR2-positive area (F), CatS-positive area (G), and MMP-9-positive area (H) percentages. Representative images are shown to the right panels. Scales: 100 µm. Numbers and genotypes of mice are indicated in the legends.