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. 2017 Apr 12;7:847. doi: 10.1038/s41598-017-00977-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TLR7 deficiency reduces aortic arch atherosclerotic lesion SMC loss and cell apoptosis in male Apoe ^−/− mice. (A) Media SMC loss grade. Scale: 200 µm. (B) Media TUNEL-positive apoptotic cell number per section. Scale: 100 µm. (C) Intima TUNEL-positive apoptotic cell number per section. Scale: 100 µm. Media with clear elastic fibers and intima are framed. Representative images are shown to the middle panels. (D) Immunofluorescent double staining detected cleaved caspase-3 (Casp)-positive apoptotic SMC in the intima. Scale: 200 µm. Inset scale: 100 µm. (E) Cleaved caspase-3 (Casp)-positive apoptotic SMC in the media. Scale: 100 µm. (F) Cleaved caspase-3 (Casp)-positive apoptotic macrophages (Mac) in the lesions. Scale: 200 µm. Inset scale: 100 µm. Arrows indicate apoptotic cells. Numbers and genotypes of mice are indicated in the legends.