Table 1.
Animal characteristics and liver composition of wild-type and PPARδIEC-KO mice with and without GW501516 treatment on low fat diet.
| wild-type | PPARδIEC-KO | wild-type GW501516 | PPARδIEC-KO GW501516 | |
|---|---|---|---|---|
| Food intake (g/24 h) | 3.6 ± 0.5 | 3.8 ± 0.6 | 3.9 ± 1.1 | 3.7 ± 1.1 |
| Body weight (g) | 26.5 ± 2.2 | 25.9 ± 2.6 | 26.2 ± 1.3 | 25.0 ± 1.8 |
| Liver weight (% of body weight) | 3.9 ± 0.3 | 4.1 ± 0.3 | 4.9 ± 0.4*** | 4.8 ± 0.3### |
| Liver cholesterol (µmol/g) | 4.2 ± 0.2 | 4.0 ± 0.3 | 4.0 ± 0.3 | 4.1 ± 0.1 |
| Liver TG (µmol/g) | 7.9 ± 0.9 | 10.6 ± 2.0 | 11.1 ± 4.4 | 7.3 ± 1.4 |
| Liver phospholipids (µmol/g) | 17.3 ± 1.1 | 17.3 ± 1.0 | 16.9 ± 1.0 | 17.8 ± 0.5 |
| Plasma TG (mmol/l) | 1.2 ± 0.3 | 0.9 ± 0.4 | 1.5 ± 0.4 | 0.8 ± 0.3 |
| Plasma cholesterol (mmol/l) | 3.5 ± 1.0 | 3.5 ± 0.9 | 4.7 ± 0.6 | 4.1 ± 0.4 |
***Significantly different from wild-type (p < 0.001); ###Significantly different from PPARδIEC-KO (p < 0.001); Values are presented as means ± SD (n = 6–7).