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. 2017 Apr 13;7:874. doi: 10.1038/s41598-017-00923-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

MMP2/9 are major players in human AdMSC immunoregulatory mechanisms and suppressive potency. The significant decrease in AdMSC suppressive capacity in inhibition experiments confirm that MMP2/9 are major players in the suppressive potency of human AdMSC. CSFE labeled PBMC, stimulated with anti-CD3 antibody (1 μg/ml), were cultured alone or with AdMSC, for 5days, with or without the MMP2 and MMP9 inhibitor - SB-3CT (0.4 ug/ml and 4 ug/ml). The cells were acquired in FACS CantoII flow cytometer using the program DIVA for acquisition and Flow Jo for analysis. A total of 300,000 events were analyzed within the lymphocyte gate selected by size (FSC) and granularity (SSC). Paired t test: p = 0.0048 (0.4 ug/ml), p = 0.0162 (4 ug/ml).