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. 2017 Apr 13;7:874. doi: 10.1038/s41598-017-00923-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Specific Positive correlations of MMP9 gene expression upregulation in AdMSC, exclusively found in the assays displaying high immunosuppressive activity. The increase of MMP9 was positively correlated with the increase of CCL22 (A) (p < 0.05), RUNX3 (B) (p < 0.001), TNF (C) (p < 0.05), FASL (D) (p < 0.05) and SEMAD4 (E) (p < 0.05), only in highly suppressive AdMSC. Several other positive exclusive correlations among increases in gene expressions were found in assays with high inhibition of T cell proliferation (>50%). The correlation coefficients are shown in graphs, using Spearman correlation test. Definitions of all abbreviations are discriminated on Supplemental Table S1.