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. 2017 Apr 13;7:874. doi: 10.1038/s41598-017-00923-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Network for T cells and AdMSC correlated gene upregulation in assays with high suppressive activity. (A) Representative network built, using IPA software, for the genes or “focus molecules” that presented positive correlation in gene expression with IL-4 in T cells, only in the assays with highly suppressive AdMSC. (MMP9, LGALS1, LRRC31, SOCS3, TGFB1, BCL2, CCR8, FOXP3, GATA, HLAG and IDO). (B) Representative network built, using IPA software, for the genes or “focus molecules” that presented positive correlation in gene expression with TNF in AdMSC, only in the assays in which AdMSC presented high suppressive activity. (MMP9, HLAG and LIF). The network is represented in a subcellular layout, placing the nodes into a view of subcellular compartments. The genes are represented in graduation of red and green based on their fold change in expression. The white open nodes indicate molecules not identified in this analysis, but associated with the regulation of some of the genes analyzed. The green edges represent inhibition and red, activation.