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. 2017 Apr 18;7:894. doi: 10.1038/s41598-017-00966-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Combination treatment with CDDP and PNA3 reduces cell invasion, and HOTAIR target gene expression in breast and ovarian cancer cells. (A) A2780_CR5 or (B) SKBR-3 cells were treated with either PNA3 or control PNA (1 μM) or transfected with either dsiGFP or dsiHOTAIR for 24 hrs and invasion assays were performed. Representative images of invading cells were counted under a light microscope (20X magnification) and normalized to control (C) A2780_CR5 and (D) SKBR3 cells were treated with either PNA3 or control PNA (1 μM) for 48 hrs and qPCR was performed for HOTAIR targets: IL-6, MMP-9, ABL-2, LAMB3, LAMC2, PCDH10, PCDHB5, IKBA, JAM2, and HOXD13. Genes were omitted from certain cell lines due to undetectable endogenous expression. Asterisks indicate P < 0.05 (*) or P < 0.01 (**).