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. 2017 Apr 18;7:897. doi: 10.1038/s41598-017-00952-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Schematic of the building gene expression profile models for the healthy adult human brain. (b) Distribution of reproducible gene expression patterns across distinct brain structures for expression profile model, MD1. (c) Number of unique brain structures (BS) that pass or fail the gene expression pattern selection criteria for models, MD1 to MD4. (d) Brain structure based gene enrichment. Top ten brain structures with highest number of genes showing significant and differential expression across four models.