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. 2017 Apr 28;2017:7079645. doi: 10.1155/2017/7079645

Figure 7.

Figure 7

Additive IOP-lowering effect of ripasudil with dorzolamide/timolol fixed combination. Monkeys were administered vehicle + 1% dorzolamide/0.5% timolol fixed combination (▲) or 0.4% ripasudil + 1% dorzolamide/0.5% timolol fixed combination (◆) into one eye (n = 5). IOP were measured before and 1, 2, 3, 4, 6, and 8 h after instillation. 1% dorzolamide/0.5% timolol fixed combination was administered 5 min after instillation of vehicle or 0.4% ripasudil. All data are presented as means ± SEs. ∗P < 0.05, compared with vehicle + 1% dorzolamide/0.5% timolol (Student's t-test).