Table 1.
Demographic and phenotypic features of SICCA participants classified with primary Sjögren’s syndrome, stratified by presence or absence of anti-centromere antibodies
| Feature | SS by ACR
|
||
|---|---|---|---|
| ACA positive (n=82) |
ACA negative (n=1279) |
p-value1 | |
| Categorical variables2 | N (%) | N (%) | |
| Female | 80 (99) | 1189 (93) | 0.0379 |
| Caucasian | 24 (30) | 576 (45) | 0.0077 |
| Dry mouth symptoms | 77 (95) | 1145 (90) | 0.1289 |
| Dry eye symptoms | 74 (91) | 1071 (84) | 0.0826 |
| Parotid gland enlargement on exam | 18 (22) | 245 (19) | 0.5635 |
| Joint pain or swelling | 37 (45) | 689 (54) | 0.1380 |
| ANA≥1:320 | 82 (100) | 715 (56) | <0.0001 |
| Anti-SSA or -SSB | 24 (29) | 1047 (82) | <0.0001 |
| Rheumatoid factor | 32 (39) | 768 (60) | 0.0003 |
| IgG>1445 mg/dL | 25 (30) | 738 (58) | <0.0001 |
| C4< 16 mg/dL | 10 (12) | 232 (18) | 0.2321 |
| WBC≤4000/mm3 | 13 (16) | 288 (23) | 0.1715 |
| Schirmer’s ≤5 mm/5 min | 58 (71) | 657 (52) | 0.0013 |
| UWS <0.1 ml/min | 78 (95) | 757 (59) | <0.0001 |
| Focus score ≥2 | 58 (71) | 681 (53) | 0.0020 |
| F/SLS or SCS | 34 (42) | 455 (36) | 0.2871 |
| History of Raynaud’s | 51 (62) | 359 (28) | <0.0001 |
| Sclerodactyly | 13 (16) | 14 (1) | <0.0001 |
| Dilated capillary loops | 16 (20) | 64 (5) | <0.0001 |
| Matted telangiectasia | 9 (11) | 66 (5) | 0.0390 |
| Oral mucosal telangiectasia | 12 (15) | 83 (6) | 0.0113 |
| Continuous variables | Median [25th, 75th percentile] | Median [25th, 75th percentile] | |
| Age | 59 [52,67] | 52 [42,62] | <0.0001 |
| Dry mouth duration | 4.0 [1.8,10.3] | 3.6 [1.3,8.9] | 0.1886 |
| Dry eye duration | 5.6 (1.9,13.9) | 4.3 [1.6,9.3] | 0.1526 |
| Maximum OSS | 9.5 [6,11] | 8.0 [5,11] | 0.0122 |
| Minimum Schirmer value | 4 [2,6] | 5 [3,9] | 0.0003 |
| UWS, ml/min | 0.08 [0–0.29] | 0.37 [0.09,0.81] | <0.0001 |
| Focus score | 2.8 [2.0,4.9] | 2.5 [1.4,4.3] | 0.0440 |
1
Fisher exact test for categorical variables and Wilcoxon rank sum test for continuous variables
2
Denominators may vary due to missing observations for some variables.
Abbreviations: ACA: anti-centromere antibodies; ANA: antinuclear antibody; IgG: immunoglobulin G; C4: complement 4; F/SLS: focal/sclerosing lymphocytic sialadenitis; SCS: sclerosing chronic sialadenitis; UWS: unstimulated whole saliva