Table 2.

Multivariate models assessing the association of selected phenotypic features of Sjögren’s syndrome with salivary and lacrimal gland function outcome measures

A. “Unstimulated whole saliva flow <0.1 ml/min vs ≥0.1 ml/min”
Phenotypic feature	Unadjusted OR	P value	Adjusted OR (95% CI)	P value
Age ≥60 years	2.04 (1.60–2.62)	<0.0001	2.12 (1.64–2.77)	<0.0001
Female gender	2.14 (1.39–3.30)	0.0005	1.92 (1.23–3.02)	0.0043
Anti-SSA and/or -SSB	0.96 (0.74–1.26)	0.7909	1.35 (0.99–1.82)	0.0513
Focus score≥2	2.59 (2.07–3.25)	<0.0001	2.50 (1.98–3.15)	<0.0001
ACA	13.42 (5.54–44.18)	<0.0001	12.24 (4.91–41.02)	<0.0001

B. “ Schirmer’s <5 mm/5 min vs ≥5 mm/5 min”
Phenotypic feature	Unadjusted OR	P value	Adjusted OR (95% CI)	P value
Age ≥60 years	1.40 (1.11–1.77)	0.0041	1.46 (1.14–1.86)	0.0022
Female gender	1.02 (0.66–1.58)	0.9229	1.18 (0.76–1.84)	0.4694
Anti-SSA and/or -SSB	1.28 (0.98–1.66)	0.0663	1.55 (1.17–2.07)	0.0026
Focus score ≥2	2.02 (1.62–2.52)	<0.0001	1.97 (1.58–2.46)	<0.0001
ACA	2.21 (1.37–3.66)	0.0009	2.52 (1.50–4.36)	0.0004

Abbreviations: ACA: anticentromere antibody