Table 1.
Characteristics of the Joslin ESRD Cohort according to category of progressive renal decline
| CATEGORY OF PROGRESSIVE RENAL DECLINE | |||||
|---|---|---|---|---|---|
| Characteristics | Very Fast | Fast | Moderate | Slow | |
| N=89 | N=79 | N=123 | N=73 | P | |
| Men | 40.5% | 58.2% | 56.1% | 48.0% | 0.28 |
| Age at T1D Dx (y) | 13 (9, 18) | 12 (7, 16) | 13 (8, 17) | 10 (6, 16) | 0.08 |
| At entry to follow-up (first serum creatinine counted): | |||||
| Duration of T1D (y) | 17 (14, 22) | 19 (15, 28) | 18 (15, 25) | 23 (18, 28) | 0.13* |
| Age (y) | 32 (27, 38) | 34 (28, 40) | 33 (25, 40) | 33 (29, 42) | 0.22* |
| HbA1c (%) | 10.6 (8.7, 12.4) | 9.8 (8.7, 11.0) | 9.2 (8.2, 10.0) | 8.9 (7.9, 10.3) | <0.001 |
| ACR g albumin/g creatinine | 1.8 (0.5, 3.3) | 1.9 (0.5, 2.6) | 1.1 (0.5, 2.3) | 0.8 (0.5, 1.7) | 0.015 |
| eGFR ml/min | 84 (67, 108) | 78 (63, 103) | 77 (63, 97) | 49 (38, 69) | <0.001 |
| During follow-up | |||||
| eGFR slopes (ml/min/year) | −22 (−31, −18) | −12 (−13, −11) | −7.5 (−8.7, −6.4) | −3.7 (−4.2, −2.7) | By design |
| Time to ESRD (y) | 3.2 (2.2, 4.0) | 5.7 (4.4, 7.1) | 8.9 (6.7, 11.7) | 10.7 (7.6, 14.5) | By design |
| At onset of ESRD | |||||
| Duration of T1D at ESRD onset(y) | 20 (17, 26) | 25 (22, 33) | 28 (24, 34) | 34 (31, 40) | <0.001* |
| Age at ESRD onset (y) | 36 (30, 41) | 40 (34, 46) | 42 (36, 47) | 46 (41, 53) | <0.001* |
Data are median (1st, 3rd quartiles)
Re-analyzed data from Skupien et al. Diabete Care 2016.6