Table 2.
Distribution of categories of progressive renal decline during 6–10 years of follow-up in patients with T1D (Panel A) or T2D (Panel B) in the Joslin Kidney Studies according to category of albuminuria at entry into follow-up. At entry, eGFR was normal in all patients.
| eGFR Loss per mL/yeara | Normo-Albuminuria | Micro-Albuminuria | Proteinuria | Total |
|---|---|---|---|---|
| % (N) | % (N) | % (N) | % (N) | |
| A. In Type 1 Diabetes | ||||
| <2.9 | 91% | 78% | 49% | 81% |
| 3–4.9 | 6% | 11% | 16% | 8% |
| 5–9.9 | 2% | 7% | 19% | 7% |
| > 10 | 1% | 4% | 16% | 4% |
| Total | 100% (932)b | 100% (525)b | 100% (275)c | 100% (1732) |
| B. In Type 2 Diabetes | ||||
| <2.9 | 80% | 67% | 32% | 72% |
| 3–4.9 | 13% | 18% | 17% | 15% |
| 5–9.9 | 6% | 12% | 30% | 10% |
| > 10 | 1% | 3% | 21% | 3% |
| Total | 100% (681) | 100% (418) | 100% (82) | 100% (1181)d |
Methods of serum creatinine determination and calibration for all patients involved in the Joslin Kidney Studies are described in Skupien et al. Diabetes Care 2016.4 eGFR slopes were estimated using linear regression and multiple serum creatinine measurments performed during 6–12 years follow-up observations.
Patients from the 1st and 2nd Joslin Kidney study in T1D were included. More information about these studies are provided in publications by Perkins et al10 and Krolewski et al.17
Patients from the Joslin Proteinuria Cohort, Skupien et al. Kidney Int. 2012.5
Patients from the 2nd Joslin Kidney study in T2D were included, (Krolewski et al. personal communication).