Table 1.

General parameters in mice 20 weeks after diabetes induction with STZ and in vehicle-treated mice that served as a non-diabetic control group. Six to nine weeks prior to induction of diabetes with STZ, animals were either injected with ace2 DNA minicircle (McACE2) or given a sham injection.

Parameter	Controls	STZ	STZ/McACE2
Blood Glucose (mg/dL)	177±16*	457±36	449±32
Body weight (g)	24.3±0.4	25.9±0.6	26.1±0.6
Serum ACE2 act (RFU/ul/hr)	1.4±0.3*	2.4±0.3	497±135**
L+R Kidney Weight (g)	0.291±0.0087*	0.437±0.0138	0.415±0.0204
Kidney/Body Weight Ratio (mg/g)	12.2±0.4*	17.2±0.5	16.3±1.0
Heart Weight (g)	0.093±0.004	0.097±0.004	0.094±0.003
Heart/Body Weight (mg/g)	3.89±0.18	3.79±0.11	3.65±0.11
SBP (mmHg)	125±8	106±6	109±5

^*denotes significant differences between controls and both STZ and STZ/McACE2 (at least at p<0.05);

^**denotes a significant difference versus controls and STZ mice not pre-treated with McACE2 (p<0.05). Otherwise there were no significant differences between untreated and McACE2-treated STZ mice