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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Neuropeptides. 2016 Nov 14;64:95–99. doi: 10.1016/j.npep.2016.11.004

Fig. 1.

Fig. 1

Olcegepant attenuates CGRP-induced diarrhea in mice. Mice administered icv vehicle (Veh) did not demonstrate diarrhea (n = 5 trials), whereas a high percentage of mice administered icv CGRP had diarrhea (****p < 0.0001; n = 7 trials). Co-administration of olcegepant (olceg) (n = 4 trials) reduced the percentage of animals with CGRP-induced diarrhea compared to CGRP-treated mice (*p < 0.05; n = 4 trials), and was significantly more (^p < 0.05) than olcegepant alone (n = 2 ). Means ± range are given. Each trial included 4–18 mice.