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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Neuropeptides. 2016 Nov 14;64:95–99. doi: 10.1016/j.npep.2016.11.004

Fig. 2.

Fig. 2

Anti-CGRP antibody blocks CGRP-induced diarrhea in mice. CGRP-induced diarrhea was completely blocked by ip anti-CGRP (anti-C) (30 mg/kg, Ab3) antibody in both wildtype mice given human CGRP and nestin/hRAMP1 mice given rat CGRP, which was significantly less (*p < 0.001) than mice pre-treated by ip antibody vehicle (Veh) or ip control (Con) antibody (n = 2 trials). Anti-CGRP antibody also blocked subsequent CGRP-induced diarrhea at the 0.05 mg/kg ip human CGRP dose (n = 1 trial). All trials included 9–12 mice per trial except ip Veh + icv CGRP trials, which included 5–10 mice per trial. Means ± range are given.