Table 1.
CGRP induces diarrhea in mice.
| Treatmenta | Genotype | Diarrhea (n) |
Total (n) |
% | p b |
|---|---|---|---|---|---|
| Veh | C57BL/6J | 0 | 21 | 0 | |
| nestin/hRAMP1 | 0 | 10 | 0 | ||
| Control littermates |
0 | 15 | 0 | ||
| Total | 0 | 46 | 0 | – | |
| CGRP | C57BL/6J | 18 | 23 | 78.3 | |
| nestin/hRAMP1 | 19 | 26 | 73.1 | ||
| Control littermates |
18 | 26 | 69.2 | ||
| Total | 55 | 75 | 73.3 | Veh: p < 0.001 | |
| olceg | nestin/hRAMP1 | 0 | 6 | 0 | |
| Control littermates |
0 | 6 | 0 | ||
| Total | 0 | 12 | 0 | n.s. | |
| olceg + CGRP |
nestin/hRAMP1 | 8 | 19 | 42.1 | |
| Control littermates |
6 | 17 | 35.3 | ||
| Total | 14 | 36 | 38.9 | Veh, CGRP: p < 0.001; olceg: p < 0.05 |
a
Treatment with icv injection of vehicle (veh), CGRP, olcegepant (olceg), or co-administration of olcegepant and CGRP (olceg + CGRP).
b
p values calculated from Fisher's exact test compared to vehicle treated mice, CGRP-treated mice, or olcegepant-treated mice, as indicated (n.s. = not significant).