Table 2.
Prevention of CGRP-induced diarrhea by anti-CGRP antibodies.
| Pre-treatmenta | Treatmentb | Diarrhea (n) |
Total (n) |
% | p c |
|---|---|---|---|---|---|
| Veh | icv CGRP | 13 | 15 | 86.7 | – |
| Con Ab | 15 | 21 | 71.4 | n.s. | |
| Anti-C Ab | 0 | 22 | 0 | Veh, Con Ab: p < 0.001 |
|
| Con Ab | ip CGRP (0.05 mg/kg) |
7 | 9 | 77.8 | – |
| Anti-C Ab | 0 | 8 | 0 | Con Ab: p < 0.005 |
a
Pre-treatment with ip injection of vehicle (Veh), control antibody (Con Ab), or anti-CGRP antibody (anti-C Ab).
b
Treatment with CGRP by icv or ip injections. Note that ip injected animals had been injected with icv CGRP 3 days prior.
c
p values calculated from Fisher's exact test compared to vehicle-treated mice, or control antibody-treated mice, as indicated (n.s. = not significant).