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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Osteoarthritis Cartilage. 2016 Nov 14;25(6):914–925. doi: 10.1016/j.joca.2016.11.004

Figure 5. Effect of longer and sustained CCR2 blockade on cartilage and bone damage.

Figure 5

(A) Scheme of RS-504393 treatment at different DMM-induced OA stages. (B) OARSI scoring (N=6 for each of the experimental points described) with (C) representative sections at each time point (scale bars 100 µm), (D) bone sclerosis by μ-CT (for untreated samples, N=5 for both Sham and DMM at each of the time points analyzed; for RS-504393 treated samples, N= 5 for both Sham and DMM at each of the time points analyzed) and (E) osteophyte size scoring (N=6 for each of the experimental points described) were obtained from DMM/Sham-operated knees at 8 and 12 weeks after surgery, treated with or without RS-504393 at the time indicated in scheme A. All graphs represent the mean ± standard deviation. Significance was set at P < 0.05.