Table 1.
Clinical Characteristics.
| Total | Normotensives | Controlled hypertensives | Uncontrolled hypertensives | P-values* | |
|---|---|---|---|---|---|
| N | 64 | 21 | 22 | 21 | |
| Age in years mean ± SD | 72 ± 7 | 72 ± 7 | 71 ± 8 | 71 ± 7 | 0.80 |
| Males:Female | 21:43 | 7:14 | 7:15 | 7:14 | 0.99 |
| never:former:current smoker | 31:26:7 | 10:10:1 | 9:9:4 | 12:7:2 | 0.57 |
| # with Diabetes | 14 | 3 | 5 | 6 | 0.53 |
| # with PVD | 10 | 1 | 5 | 4 | 0.24 |
| # with <8th grade Education | 35 | 12 | 12 | 11 | 0.95 |
| IQ Z-score mean ± SD | 0.08 ± 0.81 | 0.13 ± 0.97 | 0.06 ± 0.80 | 0.06 ± 0.68 | 0.95 |
| Memory Z-score mean ± SD | 0.07 ± 0.79 | 0.03 ± 0.88 | 0.15 ± 0.75 | 0.03 ± 0.73 | 0.85 |
| Executive Function Z-score mean ± SD | –0.14 ± 0.81 | –0.12 ± 0.84 | –0.07 ± 0.80 | –0.24 ± 0.81 | 0.80 |
| Processing Speed Z-score mean ± SD | 0.01 ± 0.35 | –0.03 ± 0.30 | 0.07 ± 0.40 | –0.02 ± 0.34 | 0.54 |
| Language Z-score mean ± SD | 0.01 ± 0.75 | 0.15 ± 0.89 | –0.01 ± 0.69 | –0.11 ± 0.67 | 0.54 |
| Total Cerebral Volume cc ± SD | 1138 ± 118 | 1137 ± 99 | 1130 ± 118 | 1146 ± 139 | 0.91 |
| Gray Matter Fraction ± SD | 0.56 ± 0.02 | 0.57 ± 0.02 | 0.56 ± 0.02 | 0.56 ± 0.02 | 0.75 |
| WMH Volume cc mean ± SD | 7.7 ± 9.1 | 5.6 ± 7.7 | 9.0 ± 8.3 | 8.4 ± 11.1 | 0.45 |
| WMH Brain Fraction mean ± SD %† | 0.66 ± 0.73 % | 0.48 ± 0.61% | 0.78 ± 0.70% | 0.70 ± 0.85% | 0.38 |
WMH, white matter hyperintensities; SD, standard deviation; PVD, peripheral vascular disease.
*
P-values reflect Chi-squared test for gender, smoking, diabetes, PVD, and education, One-way ANOVA for all others.
†
Total WMH Volume/Total Intracranial Volume.